Used primarily in molecular biology and biochemistry, this solution is essential for RNA-related experiments. It serves as a buffering agent to maintain stable pH conditions during RNA extraction, purification, and enzymatic reactions like reverse transcription or PCR. Its RNase-free property ensures RNA integrity by preventing degradation, making it critical for sensitive applications such as RNA sequencing, cDNA synthesis, and gene expression analysis. Additionally, it is employed in precipitation protocols to isolate RNA or nucleic acids from aqueous solutions, enhancing yield and purity. Its compatibility with various enzymes and reagents makes it a versatile component in laboratory workflows.