DNA-grade sodium acetate solution is widely used in molecular biology for nucleic acid precipitation. It is particularly effective in ethanol precipitation protocols to isolate and purify DNA or RNA from aqueous solutions. The solution helps to neutralize the negative charges on the phosphate backbone of nucleic acids, facilitating their aggregation and precipitation. It is also utilized in buffer preparations for various enzymatic reactions, including ligation and restriction digestion, due to its ability to maintain optimal pH conditions. Additionally, it serves as a component in hybridization buffers for techniques like Southern and Northern blotting, ensuring stable and efficient nucleic acid binding. Its high purity ensures minimal interference with sensitive molecular biology applications.