CORT108297 is primarily used in research settings to study glucocorticoid receptor (GR) activity. It acts as a selective glucocorticoid receptor modulator (SGRM), making it valuable for understanding the mechanisms of GR signaling and its role in various physiological processes. Researchers utilize it to explore the effects of GR modulation on inflammation, metabolism, and stress responses. Its selectivity allows for targeted studies without the broad effects associated with traditional glucocorticoids, making it a useful tool in developing potential therapies for conditions like metabolic disorders, immune-related diseases, and stress-related pathologies. Additionally, it aids in investigating the balance between beneficial and adverse effects of GR activation, contributing to the development of safer and more effective treatments.