PAMP-12 is a peptide fragment derived from proadrenomedullin, known for its role in modulating cardiovascular and inflammatory responses. It exhibits potent vasodilatory effects, making it relevant in studies focused on blood pressure regulation and endothelial function. The trifluoroacetate (TFA) salt form enhances solubility and stability for experimental use.

In research, PAMP-12 is used to investigate mechanisms of vasoregulation and neurohormonal signaling. It has been shown to inhibit catecholamine release from adrenal chromaffin cells, suggesting a role in dampening sympathetic nervous system activity. This property is explored in models of hypertension and heart failure.

Additionally, PAMP-12 demonstrates antimicrobial activity against certain pathogens, indicating potential immune-modulating functions. Its ability to influence both vascular tone and innate immunity makes it a subject of interest in sepsis and inflammatory disease research.

Due to its short half-life in vivo, PAMP-12 is primarily used in controlled laboratory settings, including in vitro assays and animal models, to dissect signaling pathways and evaluate therapeutic targets related to cardiovascular and immune function.