ELA-14 (human) TFA is primarily used in biomedical research, particularly in studies related to cardiovascular function and stem cell biology. It acts as an agonist for the apelin receptor (APJ), which plays a key role in regulating heart contractility, blood pressure, and fluid homeostasis. Due to its ability to mimic the effects of the endogenous peptide apelin, ELA-14 is valuable in investigating signaling pathways involved in cardiac development and function.

It is also used in regenerative medicine research, where activation of the apelin pathway has been shown to enhance the differentiation and migration of endothelial progenitor cells, supporting blood vessel formation. Its stability in the presence of TFA makes it suitable for in vitro and in vivo experimental models, especially in studies exploring potential therapies for heart failure, ischemic injury, and other cardiovascular diseases.