SGC2085
10mM in DMSO
Reagent
Code: #233982
CAS Number
1821908-48-8
blur_circular Chemical Specifications
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Molecular Information
Weight
312.41 g/mol
Formula
C₁₉H₂₄N₂O₂
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Registry Numbers
MDL Number
MFCD30537226
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Storage & Handling
Storage
-20°C
description Product Description
SGC2085 is a potent and selective inhibitor of the protein arginine methyltransferase PRMT8, which plays a role in epigenetic regulation and cellular signaling. Its primary application lies in research settings, particularly in the study of epigenetic mechanisms and their influence on gene expression and cell behavior. Due to its selectivity for PRMT8, SGC2085 is used as a chemical probe to dissect the biological functions of this enzyme in neuronal development and function, as PRMT8 is predominantly expressed in the central nervous system.
Researchers use SGC2085 to investigate the role of PRMT8 in brain-related disorders, including neurodegenerative diseases and psychiatric conditions. It also supports drug discovery efforts by helping validate PRMT8 as a therapeutic target. Additionally, SGC2085 contributes to understanding the broader family of PRMT enzymes and their involvement in cancer, where aberrant methylation events can drive disease progression. Its application remains mainly confined to in vitro and cellular assays in academic and pharmaceutical research.
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