UNC0379 is primarily used in biochemical research as a selective inhibitor of the enzyme lysine methyltransferase SETD8. Its application is significant in studying the role of SETD8 in various cellular processes, including DNA repair, cell cycle regulation, and chromatin remodeling. Researchers utilize UNC0379 to explore the potential therapeutic effects of inhibiting SETD8 in cancer treatment, as this enzyme is often overexpressed in certain types of cancer. Additionally, it serves as a valuable tool in understanding epigenetic regulation and its impact on gene expression, providing insights into the development of novel epigenetic therapies.