MS023 dihydrochloride is primarily used in biochemical research as a potent and selective inhibitor of protein arginine methyltransferases (PRMTs), particularly PRMT4 (also known as coactivator-associated arginine methyltransferase 1 or CARM1). Its application is significant in studying the role of arginine methylation in various cellular processes, including gene expression regulation, signal transduction, and protein function. Researchers utilize it to investigate the implications of PRMT4 inhibition in cancer biology, as abnormal methylation patterns are often linked to tumorigenesis. Additionally, it serves as a valuable tool in understanding epigenetic mechanisms and developing potential therapeutic strategies targeting PRMTs in diseases such as cancer and metabolic disorders. Its high selectivity makes it a preferred compound for in vitro and in vivo studies aimed at elucidating the biological functions of PRMT4.