EPZ020411 hydrochloride is primarily used in research settings as a potent and selective inhibitor of the protein methyltransferase EZH2, which is part of the Polycomb Repressive Complex 2 (PRC2). This compound is particularly valuable in studying the role of EZH2 in gene silencing and its involvement in various cancers, such as lymphomas and solid tumors. By inhibiting EZH2, it helps researchers understand the mechanisms of epigenetic regulation and explore potential therapeutic strategies for EZH2-driven malignancies. Additionally, it is utilized in preclinical studies to assess its efficacy in reducing tumor growth and metastasis, providing insights into the development of targeted cancer therapies.