GSK-J2 is primarily used in research settings to study the role of histone demethylases, particularly the Jumonji domain-containing proteins, in cellular processes. It is widely applied in biochemical and cellular assays to investigate epigenetic regulation, gene expression, and chromatin remodeling. Researchers utilize GSK-J2 to explore its effects on cancer cell proliferation, differentiation, and apoptosis, providing insights into potential therapeutic targets for diseases like cancer. Additionally, it is employed in studies focused on stem cell biology and developmental processes, helping to elucidate the mechanisms underlying cellular identity and fate determination. Its application extends to understanding the impact of histone modifications on various physiological and pathological conditions.