Used in histopathology to visualize reticular fibers in tissue samples, particularly in liver, spleen, and bone marrow. Helps in diagnosing liver diseases such as cirrhosis by showing disruption of the normal reticulin framework. Also valuable in identifying tumors, especially to distinguish between different types of neoplasms based on the pattern of reticular fiber distribution. Commonly used in conjunction with other stains to assess architectural integrity in biopsies.