JNJ-7777120 is primarily utilized in research settings to study the role of histamine H4 receptors in various physiological and pathological processes. It serves as a selective antagonist for these receptors, making it a valuable tool for investigating inflammatory and immune responses. Researchers use it to explore its potential in modulating conditions such as allergic reactions, asthma, and autoimmune diseases. Additionally, it aids in understanding the receptor's involvement in pain perception and its potential as a therapeutic target for chronic pain management. Its application extends to preclinical studies aimed at developing novel treatments for inflammatory disorders.