Clobenpropit dihydrobromide is primarily used in research settings as a potent and selective antagonist of the histamine H3 receptor. Its application is significant in studying the role of histamine H3 receptors in the central nervous system, particularly in areas related to cognitive function, sleep-wake regulation, and neuropsychiatric disorders. Researchers utilize this compound to investigate potential therapeutic strategies for conditions such as Alzheimer's disease, narcolepsy, and attention deficit hyperactivity disorder (ADHD). Additionally, it serves as a valuable tool in pharmacological studies to understand the modulation of neurotransmitter release, as H3 receptors are known to influence the release of key neurotransmitters like acetylcholine, dopamine, and serotonin.