HIF-2α-IN-1 is primarily used in research settings to study hypoxia-inducible factor 2-alpha (HIF-2α) signaling pathways. It serves as a selective inhibitor, helping scientists understand the role of HIF-2α in various biological processes, particularly in conditions like cancer and metabolic disorders. By blocking HIF-2α activity, researchers can investigate its impact on tumor growth, angiogenesis, and cellular responses to low oxygen levels. This compound is also valuable in exploring potential therapeutic strategies targeting HIF-2α in diseases where its dysregulation plays a critical role. Its application extends to preclinical studies aimed at developing novel treatments for cancers and other hypoxia-related conditions.