Tert-Butyl (1-(((S)-1-((R)-3-Benzyl-3-(1,2,2-Trimethylhydrazinecarbonyl)Piperidin-1-Yl)-3-(1H-Indol-3-Yl)-1-Oxopropan-2-Yl)Amino)-2-Methyl-1-Oxopropan-2-Yl)Carbamate
98%
Reagent
Code: #243896
CAS Number
883572-59-6
blur_circular Chemical Specifications
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Molecular Information
Weight
646.82 g/mol
Formula
C₃₆H₅₀N₆O₅
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Storage & Handling
Storage
2-8°C
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a linker component that connects a target protein binder to an E3 ubiquitin ligase recruiter, enabling targeted protein degradation. Its tert-butyloxycarbonyl (Boc) protected amine group allows for controlled deprotection and further conjugation in multi-step synthetic routes. The structure supports solubility and stability during solid-phase or solution-phase peptide-like assembly, making it valuable in developing novel therapeutics for cancer, neurodegenerative diseases, and other conditions involving dysregulated proteins.
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