3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
98%
Reagent
Code: #240305
Alias
Triazoperazine hydrochloride; 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazole[4,3-a]pyrazine hydrochloride; 3-(trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazole(4,3-A)pyrazine salt; 3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazole[4,3-A]popyrazine Hydrochloride; Sitagliptin intermediate 2; Sitagliptin phosphate side chain/3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine hydrochloride; Sitagliptin phosphate intermediate; 3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]piperazine hydrochloride
CAS Number
762240-92-6
blur_circular Chemical Specifications
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Molecular Information
Weight
228.6 g/mol
Formula
C₆H₈ClF₃N₄
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Registry Numbers
MDL Number
MFCD09817638
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Physical Properties
Melting Point
236-246°C
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Storage & Handling
Storage
2~8℃
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of biologically active compounds, particularly in the development of central nervous system agents. Its structure supports binding to neurological receptors, making it valuable in creating potential treatments for psychiatric and neurological disorders. The compound's trifluoromethyl group enhances metabolic stability and bioavailability, which is advantageous in drug design. It is also employed in structure-activity relationship (SAR) studies to optimize potency and selectivity of new therapeutic candidates.
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