4-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole
98%
Reagent
Code: #192724
CAS Number
91679-37-7
science Other reagents with same CAS 91679-37-7
blur_circular Chemical Specifications
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Molecular Information
Weight
310.39 g/mol
Formula
C₂₂H₁₈N₂
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Registry Numbers
MDL Number
MFCD27982126
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Physical Properties
Melting Point
>103 °C(dec.)
Boiling Point
529.4±29.0 °C(Predicted)
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Storage & Handling
Density
1.151±0.06 g/cm3(Predicted)
Storage
Room temperature, seal, dry
description Product Description
Used primarily as a key intermediate in the synthesis of antifungal medications, particularly in the production of imidazole-based antifungals such as ketoconazole and related derivatives. Its structure allows for effective interaction with fungal cytochrome P450 enzymes, inhibiting ergosterol biosynthesis, which is critical for fungal cell membrane integrity. Due to its lipophilic aromatic groups and imidazole ring, it enhances drug penetration into skin, nails, and mucosal tissues, making it valuable in topical and systemic antifungal formulations. Also employed in research for developing new antimicrobial agents and in medicinal chemistry for structure-activity relationship studies.
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