4-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole

98%

Reagent Code: #192724
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CAS Number 91679-37-7

science Other reagents with same CAS 91679-37-7

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 310.39 g/mol
Formula C₂₂H₁₈N₂
badge Registry Numbers
MDL Number MFCD27982126
thermostat Physical Properties
Melting Point >103 °C(dec.)
Boiling Point 529.4±29.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.151±0.06 g/cm3(Predicted)
Storage Room temperature, seal, dry

description Product Description

Used primarily as a key intermediate in the synthesis of antifungal medications, particularly in the production of imidazole-based antifungals such as ketoconazole and related derivatives. Its structure allows for effective interaction with fungal cytochrome P450 enzymes, inhibiting ergosterol biosynthesis, which is critical for fungal cell membrane integrity. Due to its lipophilic aromatic groups and imidazole ring, it enhances drug penetration into skin, nails, and mucosal tissues, making it valuable in topical and systemic antifungal formulations. Also employed in research for developing new antimicrobial agents and in medicinal chemistry for structure-activity relationship studies.

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Size Availability Unit Price Quantity
inventory 25mg
10-20 days ฿25,330.00
inventory 50mg
10-20 days ฿43,050.00

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4-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole
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Used primarily as a key intermediate in the synthesis of antifungal medications, particularly in the production of imidazole-based antifungals such as ketoconazole and related derivatives. Its structure allows for effective interaction with fungal cytochrome P450 enzymes, inhibiting ergosterol biosynthesis, which is critical for fungal cell membrane integrity. Due to its lipophilic aromatic groups and imidazole ring, it enhances drug penetration into skin, nails, and mucosal tissues, making it valuable in topical and systemic antifungal formulations. Also employed in research for developing new antimicrobial agents and in medicinal chemistry for structure-activity relationship studies.
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