(2-(((5-((4-Fluorophenyl)carbamoyl)pyrimidin-2-yl)thio)methyl)-4-(trifluoromethoxy)phenyl)boronic acid
≥98%
Reagent
Code: #189486
CAS Number
1648843-04-2
blur_circular Chemical Specifications
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Molecular Information
Weight
467.20 g/mol
Formula
C₁₉H₁₄BF₄N₃O₄S
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Registry Numbers
MDL Number
MFCD28502254
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Storage & Handling
Density
1.53±0.1 g/cm3(Predicted)
Storage
2-8°C, sealed, dry, inert gas
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of kinase inhibitors, particularly for targeted cancer therapies. Its boronic acid functional group enables Suzuki-Miyaura cross-coupling reactions, facilitating the construction of complex biaryl structures found in bioactive molecules. Commonly employed in the development of tyrosine kinase and BTK inhibitors due to its ability to enhance binding affinity and selectivity. Also utilized in medicinal chemistry for optimizing pharmacokinetic properties such as metabolic stability and membrane permeability.
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