1-(5-Chloropyrimidin-2-yl)azetidine-3-carboxylic acid
95%
Reagent
Code: #163376
CAS Number
1289386-16-8
science Other reagents with same CAS 1289386-16-8
blur_circular Chemical Specifications
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Molecular Information
Weight
213.62 g/mol
Formula
C₈H₈ClN₃O₂
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Registry Numbers
MDL Number
MFCD18837467
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used as a key intermediate in the synthesis of pharmaceutical agents, particularly in the development of kinase inhibitors for targeted cancer therapies. Its structure enables selective binding to enzyme active sites, making it valuable in drug discovery programs focused on oncology and inflammatory diseases. The compound's azetidine and chloropyrimidine moieties contribute to metabolic stability and improved pharmacokinetic profiles in final drug candidates. It is also employed in the preparation of covalent inhibitors due to the reactivity of the chlorine atom, allowing for irreversible target engagement. Commonly utilized in medicinal chemistry research for structure-activity relationship (SAR) studies to optimize potency and selectivity.
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