5-((3-Chloro-4-fluorophenyl)amino)-6-methyl-1,2,4-triazine-3(2H)-thione
97%
Reagent
Code: #156872
CAS Number
474815-01-5
blur_circular Chemical Specifications
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Molecular Information
Weight
270.71 g/mol
Formula
C₁₀H₈ClFN₄S
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Storage & Handling
Storage
Room temperature, inert gas
description Product Description
Used as a key intermediate in the synthesis of tyrosine kinase inhibitors, particularly in the development of anticancer agents. It exhibits potential in targeting epidermal growth factor receptor (EGFR) pathways, which are implicated in various cancers, including non-small cell lung cancer. Its structure allows for modification to enhance binding affinity and selectivity toward mutant forms of EGFR, making it valuable in designing targeted therapies. Additionally, it has been explored in medicinal chemistry research for optimizing drug candidates with improved pharmacokinetic profiles and reduced resistance.
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