4-Chloro-2-(6-chloro-4-oxo-1,4-dihydroquinazolin-2-yl)phenyl dihydrogen phosphate
95%
Reagent
Code: #156687
CAS Number
147394-94-3
blur_circular Chemical Specifications
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Molecular Information
Weight
387.1 g/mol
Formula
C₁₄H₉Cl₂N₂O₅P
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Registry Numbers
MDL Number
MFCD16657028
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Physical Properties
Boiling Point
654.9±65.0 °C(Predicted)
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Storage & Handling
Density
1.78±0.1 g/cm3(Predicted)
Storage
2-8°C, sealed, dry
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of tyrosine kinase inhibitors, particularly those targeting epidermal growth factor receptor (EGFR) pathways. Its structure supports the development of anticancer agents by enabling selective inhibition of kinase activity involved in tumor growth and progression. Commonly employed in the preparation of active pharmaceutical ingredients (APIs) for targeted cancer therapies, especially in non-small cell lung cancer (NSCLC) treatment. Also utilized in structure-activity relationship (SAR) studies to optimize potency, selectivity, and metabolic stability of kinase inhibitor candidates.
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