Used as a key reagent in organic synthesis, particularly for the introduction of the hydroxamate group. It enables efficient conversion of carboxylic acids to hydroxamic acids, which are important in medicinal chemistry—especially in the development of metalloenzyme inhibitors such as histone deacetylase (HDAC) inhibitors for cancer therapy. Its cyclic structure allows for controlled reactivity and improved selectivity in acylation reactions. Commonly employed in peptide modification and bioconjugation due to its ability to form stable hydroxamate linkages under mild conditions. Also utilized in agrochemical synthesis for building nitrogen- and oxygen-containing heterocycles.