MAL-PEG-MAL is widely used in bioconjugation and drug delivery systems due to its ability to link molecules through its maleimide groups. It is particularly effective in attaching proteins, peptides, or antibodies to other biomolecules or nanoparticles, enhancing targeted delivery. In cancer therapy, it is employed to create antibody-drug conjugates, improving the precision of drug delivery to tumor cells. Additionally, it is utilized in the development of hydrogels for tissue engineering, where it helps in cross-linking polymers to form stable, biocompatible structures. Its water-soluble PEG spacer also reduces immunogenicity and improves the stability of conjugated compounds in biological environments.