Used as a selective herbicide in cereal crops, particularly wheat, to control a broad spectrum of grass and broadleaf weeds. It is effective at low application rates and works by inhibiting the enzyme acetolactate synthase (ALS), which is essential for amino acid synthesis in plants. This leads to the cessation of cell division and growth in susceptible weeds. Mesosulfuron-methyl is often formulated with safeners to protect the crop from phytotoxic effects. It is especially useful in managing herbicide-resistant weed populations and is applied post-emergence, making it suitable for integrated weed management programs. Its systemic action allows for translocation within the plant, ensuring thorough control.