Metadoxil is primarily used in the treatment of acute alcohol intoxication and chronic alcoholism. It helps to accelerate the elimination of alcohol from the blood, reducing the toxic effects on the liver and improving symptoms of intoxication. Additionally, it is employed to manage liver damage caused by excessive alcohol consumption, aiding in the restoration of normal liver function. Metadoxil is also studied for its potential benefits in improving cognitive functions impaired by alcohol abuse, making it a valuable component in comprehensive treatment plans for alcohol-related disorders.