SAHA-Bpyne is primarily utilized in chemical biology and medicinal chemistry research for its role in studying protein interactions and epigenetic regulation. It combines the histone deacetylase (HDAC) inhibitory activity of SAHA (vorinostat) with a bioorthogonal alkyne handle, enabling selective labeling and detection of HDAC proteins in complex biological systems. This compound is particularly valuable in proteomics for identifying and characterizing HDAC targets and their associated pathways. Additionally, SAHA-Bpyne is employed in the development of novel therapeutics targeting epigenetic mechanisms, offering insights into the modulation of gene expression and cellular processes. Its bifunctional design allows for both functional inhibition and subsequent visualization, making it a versatile tool in drug discovery and mechanistic studies.