1-Fluorodecane is primarily used in organic synthesis as a building block for more complex chemical compounds. Its fluorine atom makes it a valuable reagent in the development of fluorinated organic molecules, which are often used in pharmaceuticals, agrochemicals, and materials science.

In the pharmaceutical industry, it serves as an intermediate in the synthesis of fluorinated drugs, where the introduction of fluorine can enhance the biological activity, stability, and bioavailability of the compounds.

In materials science, 1-fluorodecane is utilized in the creation of fluorinated surfactants and coatings, which provide water and oil repellency, chemical resistance, and durability.

Additionally, it is employed in research and development for studying the effects of fluorine substitution in organic molecules, aiding in the design of new materials and chemicals with tailored properties.