1-Bromobenzocyclobutene is primarily used in organic synthesis as a versatile building block for constructing more complex chemical structures. Its unique cyclobutene ring makes it valuable in the development of pharmaceuticals, where it can be incorporated into drug molecules to enhance their biological activity or stability. Additionally, it serves as a key intermediate in the synthesis of polymers and advanced materials, particularly those requiring rigid or strained ring systems. In research, it is often employed in cross-coupling reactions, such as Suzuki or Heck reactions, to create novel aromatic compounds. Its reactivity also makes it useful in the study of ring-opening and ring-expansion reactions, contributing to advancements in synthetic organic chemistry.