[2-(Difluoromethyl)phenyl]methanol, 2-(Hydroxymethyl)benzal fluoride
98%
Reagent
Code: #177558
CAS Number
1018678-49-3
blur_circular Chemical Specifications
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Molecular Information
Weight
158.15 g/mol
Formula
C₈H₈F₂O
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Registry Numbers
MDL Number
MFCD26728124
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Storage & Handling
Storage
Room temperature
description Product Description
Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of fluorinated active pharmaceutical ingredients (APIs) where the difluoromethyl group enhances metabolic stability and bioavailability. Its structure allows for selective derivatization, making it valuable in medicinal chemistry for creating analogs with improved pharmacokinetic profiles. Also employed in agrochemical research for designing novel pesticides and herbicides, leveraging the fluorine atoms to increase lipophilicity and membrane permeability. Commonly utilized in late-stage functionalization due to the reactivity of the hydroxymethyl group, enabling efficient coupling reactions in drug discovery.
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