SB 216763 is widely used in biochemical and pharmacological research due to its ability to inhibit glycogen synthase kinase-3 (GSK-3). This inhibition is particularly valuable in studying cellular signaling pathways, especially those involved in diseases like Alzheimer's, diabetes, and cancer. Researchers utilize it to explore the role of GSK-3 in neuroprotection, inflammation, and cell proliferation. Additionally, it serves as a tool compound in drug discovery to identify potential therapeutic targets by modulating GSK-3 activity. Its application extends to studying Wnt signaling pathways, which are crucial in developmental biology and cancer research.