AZD1080 is primarily utilized in research settings as a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3). Its application is significant in studying the role of GSK-3 in various cellular processes, including neuronal function, metabolism, and cell signaling pathways. Researchers employ AZD1080 to investigate its potential therapeutic effects in neurodegenerative diseases such as Alzheimer's, where GSK-3 activity is implicated in disease progression. Additionally, it is used to explore its impact on mood disorders, cancer, and diabetes, as GSK-3 plays a critical role in these conditions. By inhibiting GSK-3, AZD1080 helps elucidate the enzyme's involvement in disease mechanisms and aids in the development of targeted treatments.