GSK376501A is primarily utilized in the field of medical research, particularly in the study of metabolic disorders. It is often employed as a tool compound to investigate the mechanisms of action related to insulin resistance and glucose metabolism. Researchers use it to explore potential therapeutic pathways for conditions like type 2 diabetes and obesity. Its application extends to preclinical studies, where it helps in understanding the efficacy and safety of novel treatments targeting metabolic pathways. Additionally, GSK376501A is sometimes used in biochemical assays to screen for compounds that can modulate specific biological targets involved in metabolic regulation.