Cyclobutylmagnesium bromide is primarily used in organic synthesis as a Grignard reagent. It is particularly valuable for forming carbon-carbon bonds, enabling the introduction of the cyclobutyl group into various organic molecules. This reagent is often employed in the preparation of complex pharmaceutical intermediates, where the cyclobutyl ring structure can enhance the biological activity of the compound. Additionally, it is utilized in the synthesis of specialty chemicals and agrochemicals, where its reactivity with carbonyl compounds (such as aldehydes, ketones, and esters) is leveraged to create a wide range of products. Its application is critical in research and development for designing novel compounds with specific properties.