DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) is used as a ceramide analog in skincare and cosmetic formulations to enhance skin barrier function and retain moisture. It helps in reducing transepidermal water loss, making it valuable in treating dry, sensitive, or aging skin. Commonly found in creams, lotions, and serums targeting improved skin hydration and protection.

Additionally, it acts as a glucosylceramide synthase inhibitor, playing a key role in research on lysosomal storage disorders such as Niemann-Pick disease and other sphingolipid-related conditions. By reducing glucosylceramide formation, a precursor to accumulating glycosphingolipids, it is utilized in studies of sphingolipid metabolism, cellular processes, and development of biological therapies.