Gc-globulin, derived from human plasma, plays a significant role in various medical and therapeutic applications. It is primarily known for its ability to bind and transport vitamin D and its metabolites, which is crucial for maintaining calcium homeostasis and bone health. This protein is also involved in the actin scavenging system, where it helps to prevent the harmful effects of actin released from damaged cells, thereby protecting tissues from inflammation and injury. In clinical settings, Gc-globulin is studied for its potential use in treating conditions related to vitamin D deficiency, such as osteoporosis and rickets. Additionally, its role in modulating immune responses and its potential therapeutic applications in sepsis and trauma are areas of ongoing research. The protein's ability to interact with the immune system also makes it a candidate for developing treatments for autoimmune diseases and inflammatory disorders. Overall, Gc-globulin is a versatile protein with promising applications in both preventive and therapeutic medicine.