ORG 12962 hydrochloride is primarily utilized in research settings, particularly in the field of neuroscience and pharmacology. It serves as a selective antagonist for the glycine transporter 1 (GlyT1), which plays a crucial role in regulating glycine levels in the central nervous system. By inhibiting GlyT1, this compound helps in studying the modulation of glutamatergic neurotransmission, which is essential for understanding cognitive functions, memory, and synaptic plasticity. Researchers also explore its potential therapeutic applications in neurological and psychiatric disorders, such as schizophrenia, where dysregulation of glutamatergic signaling is implicated. Additionally, it aids in investigating the role of glycine in pain perception and neuroprotection, contributing to the development of novel treatments for chronic pain and neurodegenerative diseases.