(S)-Willardiine is primarily used in neuroscience research as a selective agonist for certain glutamate receptors, particularly the AMPA and kainate subtypes. It is valuable in studying the role of these receptors in synaptic transmission, plasticity, and excitatory signaling in the central nervous system. Researchers utilize it to explore mechanisms underlying neurological disorders such as epilepsy, neurodegenerative diseases, and cognitive impairments. Additionally, it aids in the development of therapeutic compounds targeting glutamate receptor dysfunctions. Its specificity makes it a useful tool for electrophysiological and pharmacological experiments aimed at understanding brain function and disease pathology.