SDZ 220-581 ammonium salt is primarily utilized in the field of neuroscience research due to its role as a selective antagonist for the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor. This compound is instrumental in studying the mechanisms of excitatory neurotransmission in the brain, particularly in relation to neurological disorders such as epilepsy, stroke, and neurodegenerative diseases. By blocking AMPA receptors, it helps researchers understand the pathways involved in excitotoxicity, which is the process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters like glutamate. Additionally, it is used in experimental models to explore potential therapeutic interventions for conditions associated with overactive glutamate signaling. Its application extends to pharmacological studies aimed at developing new drugs that modulate AMPA receptor activity for treating brain-related disorders.