E4CPG is primarily used in neuroscience research as a selective antagonist for group I metabotropic glutamate receptors (mGluRs). It helps in studying the role of these receptors in synaptic transmission and plasticity, particularly in the central nervous system. Researchers utilize E4CPG to investigate its effects on neuronal signaling, learning, and memory processes. Additionally, it is employed in experimental models to understand its potential therapeutic applications in neurological disorders such as epilepsy, anxiety, and neurodegenerative diseases. Its ability to modulate glutamate receptor activity makes it a valuable tool for exploring the mechanisms underlying brain function and dysfunction.