DHPG is widely used in neuroscience research as a selective agonist for group I metabotropic glutamate receptors (mGluR1 and mGluR5). It plays a crucial role in studying synaptic plasticity, neuronal signaling, and the mechanisms underlying learning and memory. Additionally, DHPG is employed in investigating the pathophysiology of neurological disorders such as epilepsy, Parkinson's disease, and schizophrenia, providing insights into potential therapeutic targets. Its application extends to electrophysiological studies, where it helps elucidate the role of glutamate receptors in modulating neuronal excitability and synaptic transmission.