(2R,4R)-APDC is a potent and selective agonist for group II metabotropic glutamate receptors (mGluR2 and mGluR3), exhibiting high affinity (EC₅₀ values of approximately 0.04 μM for mGluR2 and 0.66 μM for mGluR3). It is primarily used in neuroscience research to investigate the roles of these receptors in regulating glutamate neurotransmission, synaptic plasticity, and neuronal excitability. This compound aids in studying glutamatergic signaling pathways and has applications in models of neurological and psychiatric disorders, including schizophrenia, anxiety, depression, Alzheimer's disease, Parkinson's disease, addiction, epilepsy, and chronic pain management. As a tool compound, it helps elucidate potential therapeutic targets for modulating excessive glutamate activity.