Used in neuroscience research to study glutamate receptor function, particularly AMPA-type ionotropic receptors involved in fast synaptic transmission. Helps investigate mechanisms of synaptic plasticity, learning, and memory. Also employed in studies of excitotoxicity and neurodegenerative diseases such as Alzheimer's, Parkinson's, and hypoxia-induced neuronal degeneration. Commonly applied in electrophysiological experiments to activate AMPA receptors in neurons and brain slices.

In research, scientists use (RS)-AMPA to study the effects of glutamate receptor activation on changes in neuronal electrical potentials. Additionally, it serves as a tool to test the efficacy of AMPA receptor antagonists or drugs targeting the glutamate system, which may lead to the development of new therapeutics for psychiatric and neurological disorders.