Used primarily in neuroscience research as a selective antagonist for the metabotropic glutamate receptor 5 (mGluR5), MTEP hydrochloride helps investigate the role of glutamatergic signaling in conditions such as anxiety, depression, Parkinson’s disease, and drug addiction. Its high selectivity and potency make it a valuable tool for studying synaptic transmission and neural pathways involved in cognitive and behavioral functions. It is commonly applied in in vivo and in vitro models to modulate mGluR5 activity and assess therapeutic targets for neurological and psychiatric disorders.