AMN082 free base is primarily used in neuroscience research as a selective allosteric agonist for the metabotropic glutamate receptor 7 (mGluR7). It modulates synaptic transmission and has been investigated for its potential role in studying anxiety, depression, and addiction-related behaviors. Due to its ability to cross the blood-brain barrier, it is valuable in preclinical studies exploring central nervous system disorders. AMN082 is also used to probe mGluR7 receptor function in animal models, helping to elucidate the receptor’s role in learning, memory, and neuroprotection. Its specificity makes it a useful tool compound in pharmacological studies targeting glutamatergic signaling pathways.