Zaldaride maleate is primarily used in the treatment of gastrointestinal disorders, particularly diarrhea. It functions by inhibiting the activity of calmodulin, a protein that plays a crucial role in the secretion of fluids and electrolytes in the intestines. This action helps to reduce the excessive fluid loss associated with diarrhea, making it effective in managing both acute and chronic forms of the condition. Additionally, it has been explored for its potential in treating other conditions related to abnormal fluid secretion, such as irritable bowel syndrome (IBS). Its application is especially valuable in cases where diarrhea is severe or persistent, providing relief and improving the quality of life for patients.