CGP52432 is primarily used in neuroscience research as a selective antagonist for GABAB receptors. It helps in studying the role of GABAergic neurotransmission, particularly in modulating synaptic activity and neuronal excitability. Due to its ability to block GABAB receptor function, it is applied in experiments investigating anxiety, addiction, cognition, and motor control. It is also utilized to reverse the sedative and muscle relaxant effects induced by GABAB agonists in preclinical models. Its high selectivity makes it a valuable tool for dissecting receptor-specific effects in both in vitro and in vivo studies.