CGP 35348 hydrate is primarily used in neuroscience research as a selective antagonist for GABA_B receptors. It helps in studying the role of these receptors in the central nervous system, particularly in understanding their involvement in neurotransmission, synaptic plasticity, and neurological disorders. This compound is valuable in experimental models to investigate conditions like anxiety, depression, and epilepsy, providing insights into potential therapeutic targets. Additionally, it is utilized in electrophysiological studies to block GABA_B receptor-mediated responses, aiding in the dissection of complex neural circuits.