MEN-10,376 is primarily utilized in research settings as a selective antagonist for the neurokinin-2 (NK2) receptor. Its application is significant in studying the role of NK2 receptors in various physiological processes, particularly in the gastrointestinal and respiratory systems. Researchers employ MEN-10,376 to investigate the mechanisms of smooth muscle contraction and its implications in conditions such as asthma, irritable bowel syndrome, and other disorders involving smooth muscle dysfunction. Additionally, it is used in pharmacological studies to explore the potential therapeutic effects of NK2 receptor blockade, aiding in the development of targeted treatments for related diseases.