AVE 0991 sodium salt is primarily used in research settings to study the renin-angiotensin system (RAS), particularly its protective pathways. It acts as a non-peptide agonist of the Mas receptor, which is part of the angiotensin-(1-7)/Mas receptor axis. This makes it valuable for investigating cardiovascular and renal diseases, as it helps in understanding the mechanisms of vasodilation, anti-inflammatory effects, and anti-fibrotic actions. Researchers also use it to explore its potential therapeutic benefits in conditions like hypertension, heart failure, and diabetic nephropathy. Its ability to mimic the effects of angiotensin-(1-7) without being a peptide makes it a useful tool in experimental models to assess the protective roles of the RAS pathway.