COG-133 trifluoroacetate is a synthetic peptide mimetic of apolipoprotein E (ApoE), primarily used in neuroscience research for its neuroprotective properties. It interacts with receptors such as LRP1 to attenuate neuroinflammation, reduce amyloid-beta toxicity, and promote neuronal survival in models of Alzheimer's disease and other neurodegenerative conditions. The trifluoroacetate salt form improves solubility and stability in aqueous solutions, making it ideal for in vitro cell culture and in vivo animal studies. Commonly applied in investigations of cognitive impairment mechanisms and potential therapeutic strategies.